Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) Some medications are changed and broken down by the liver. Drinking grapefruit juice while taking halofantrine might increase halofantrine levels and side effects associated with halofantrine, including abnormal heartbeat. Halofantrine Grapefruit juice seems to decrease how quickly the body breaks down halofantrine. Separate taking this medication from consuming grapefruit by at least 4 hours. Drinking grapefruit juice while taking etoposide might decrease the effects of etoposide. Etoposide (VePesid) Grapefruit might decrease how much etoposide the body absorbs. Drinking grapefruit juice while taking estrogens might increase estrogen levels and side effects associated with estrogen. Estrogens Grapefruit juice seems to decrease how quickly the body breaks down estrogens and increase how much estrogen the body absorbs. Drinking grapefruit juice while taking dextromethorphan might increase the effects and side effects of dextromethorphan. Dextromethorphan (Robitussin DM, and others) Grapefruit might decrease how quickly the body gets rid of dextromethorphan. Drinking grapefruit juice while taking cyclosporine might increase the side effects of cyclosporine. Cyclosporine (Neoral, Sandimmune) Grapefruit might increase how much cyclosporine the body absorbs. This might reduce the effects of clopidogrel. Grapefruit appears to decrease how much clopidogrel is activated by the body. Clopidogrel (Plavix) Clopidogrel needs to be activated by the body to work. Taking grapefruit juice along with clomipramine might increase the effects and side effects of clomipramine. Clomipramine (Anafranil) Grapefruit juice might decrease how quickly the body gets rid of clomipramine. Drinking grapefruit juice while taking cisapride might increase the effects and side effects of cisapride. Cisapride (Propulsid) Grapefruit juice might decrease how quickly the body gets rid of cisapride. Separate administration of celiprolol and consumption of grapefruit by at least 4 hours. This might decrease the effects of celiprolol. Celiprolol (Celicard) Grapefruit appears to decrease how much celiprolol is absorbed by the body. Drinking grapefruit juice while taking carvedilol might increase the effects and side effects of carvedilol. Carvedilol (Coreg) Grapefruit juice seems to decrease how quickly the body breaks down carvedilol. Drinking grapefruit juice while taking carbamazepine might increase the effects and side effects of carbamazepine. Carbamazepine (Tegretol) Grapefruit juice might increase how much carbamazepine the body absorbs. Drinking grapefruit juice while taking buspirone might increase the effects and side effects of buspirone. Buspirone (BuSpar) Grapefruit juice might increase how much buspirone the body absorbs.
Do not drink grapefruit juice if you are taking artemether. Drinking grapefruit juice while taking artemether might increase the effects and side effects of artemether. Artemether (Artenam, Paluther) Grapefruit juice can decrease how quickly the body breaks down artemether. Avoid drinking grapefruit juice if you are taking amiodarone. Drinking grapefruit juice might increase the effects and side effects of amiodarone. Amiodarone (Cordarone) Grapefruit juice can increase how much amiodarone the body absorbs. It's been linked with an increased risk of breast cancer in these patients. Postmenopausal adults: Postmenopausal adults should avoid drinking large amounts of grapefruit juice.
Don't use grapefruit if you have this condition. Irregular heartbeat: Eating large amounts of grapefruit or drinking grapefruit juice might worsen irregular heartbeat. People with hormone sensitive conditions should avoid grapefruit. Hormone sensitive cancers and conditions: Drinking large amounts of grapefruit juice might increase hormone levels and therefore increase the risk of hormone sensitive conditions. People with this condition should consume grapefruit juice in moderation. A heart muscle disorder (cardiomyopathy): Drinking grapefruit juice might increase the risk for abnormal heart rhythm. Stay on the safe side and stick to normal food amounts.
Special precautions & warnings: Pregnancy and breast-feeding: There isn't enough reliable information to know if grapefruit is safe to use when pregnant or breast-feeding. Grapefruit interacts with a long list of medications. If you take any medications, check with your healthcare provider before adding grapefruit to your diet or using it as a medicine. But it is possibly unsafe for postmenopausal adults to take grapefruit in large amounts. Grapefruit products are possibly safe when taken by mouth as a medicine. When taken by mouth: Grapefruit is commonly consumed as a food or juice.
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